The Prospective Recurrent Pregnancy Loss Registry (ProRPL Registry) collects detailed clinical, demographic, and psychosocial information from patients attending the BC Women’s RPL Clinic. Participation is voluntary and offered to all new and re-referred patients who meet diagnostic criteria (≥2 pregnancy losses before 20 weeks) and express interest in contributing to research. Participants complete an intake questionnaire prior to their clinic visit, covering:
- Demographic information
- Personal and family medical history
- Obstetric, gynecologic, and surgical history
- Previous pregnancy outcomes and treatments
- Mental health screening tools (PHQ-9, GAD-7, and PSS)
Clinic staff also document findings from clinical records including:
- Physical exams and ultrasound
- Consultation notes
- Laboratory and genetic investigations
- External medical records
- Prescribed treatment plans
Participants receive follow-up questionnaires annually for up to five years. These updates capture information about future pregnancies, test results, and treatment changes. This allows for real-time tracking of reproductive outcomes and emerging diagnoses.
Up to 50% of RPL cases remain unexplained. By maintaining a high-quality, prospective dataset, the ProRPL Registry enables research into the underlying mechanisms, psychosocial impacts, and long-term trajectories of RPL, supporting evidence-based care within the field of reproductive health.